Research in the Mashek laboratory focuses on the relationship between lipid metabolism and disease development. A primary emphasis is on studies involving lipid droplet biology in the context of non-alcoholic fatty liver disease, Type 2 Diabetes, cancer and aging. Our studies span a range of disciplines that ultimately link nutrition, biochemistry and physiology - in other words, we study metabolism. An important goal of the laboratory is to do research that helps us identify detailed mechanisms of disease using animal and cell models and then translate these findings to the clinic. Ultimately, we hope that by advancing our knowledge into the basic metabolism of nutrients we will come closer to understanding how metabolic diseases develop and, therefore, will be better equipped to identify new preventions or treatments.