Publications

Recent papers:

Kopczynski D, Hentschel A, Coman C, Schebb NH, Hornemann T, Mashek DG, Hartung NM, Shevchuk O, Schött HF, Lorenz K, Torta F, Burla B, Zahedi RP, Sickmann A, Kreutz MR, Ejsing CS, Medenbach J, Ahrends R. Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics. Analytical Chemistry (in press)

Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen D, Mashek DG. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy 2020;19:1-16.

Najt CP, Khan SA, Heden TD, Witthuhn BA, Perez M, Mead LE, Franklin MP, Karanja KK, Graham MJ, Mashek MT, Bernlohr DA, Parker L, Chow LS, Mashek DG. Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1. Molecular Cell 2020;77(4):810-824.

Chow LS, Manoogian E, Alvear A, Thor H, Dietsche K, Wang Q, Hodges J, Nair KS, Panda S, Mashek DG. Time restricted eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study. Obesity 2020;28(5):860-869.

Zhang E, Cui W, Lopresti M, Mashek MT, Najt CP, Hu H, Mashek DG. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting. Journal of Lipid Research 2020;61(3):338-350.

Nerstedt A, Kurhe Y, Cansby E, Caputo M, Gao L, Vorontsov E, Stahlman M, Nuñez-Durán E, Boren J, Marschall HU, Mashek DG, Saunders DN, Sihlbom C, Hoy AJ, Mahlapuu M. Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver. Journal of Lipid Research 2020;61(2):178-191.

Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Bras LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Brault JF, Zeczycki TN, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Science Advances 2019;5(9):eaax8352.

Josephrajan A, Hertzel AV, Bohm EK, McBurney MW, Ichiro-Imai S, Mashek DG, Kim DH, Bernlohr DA. Unconventional Secretion Of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins In a Sirtuin-1 Dependent Manner. Diabetes 2019;68(9):1767-1777.

Wu H, Ploeger JM, Kamarajugadda S, Mashek DG, Mashek MT, Manivel JC, Shekels LL, Lapiro JL, Albrecht JH. Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes. Hepatology Communiciations 2019;3(3):406-422.

 

 

 

Reviews/Commentaries:

Mashek DG. Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD. Molecular Metabolism (in press)

Seibert JT, Najt CP, Heden TD, Mashek DG, Chow LS. Muscle Lipid Droplets: Cellular Signaling to Exercise Physiology and Beyond. Trends in Endocrinology and Metabolism (in press)

Chow LD, Mashek DG. The microenvironment matters: the secret life of intramuscular lipid droplets. Journal of Physiology (in press)

O'Brien CM, Mulukutla BC, Mashek DG, Hu WS. Regulation of Metabolic Homeostasis in Cell Culture Bioprocesses.Trends in Biotechnology (in press)

Shang L, Mashek DG. The underpinning of PNPLA3-mediated fatty liver disease emerge. Hepatology 2020;71(1):375-377.

Schulze RJ, Sathyanarayan A, Mashek DG.  Breaking fat: the regulation and mechanisms of lipophagy. BBA - Molecular and Cell Biology of Lipids 2017;1862(10):1178-1187.

Mulukutla BC, Yongky A, Le T, Mashek DG, Hu WS. Regulation of Glucose Metabolism - A Perspective From Cell Bioprocessing. Trends in Biotechnology 2016;16:S0167-7799.

Mashek DG, Khan SA, Sathyanarayan A, Ploeger JM, Franklin MP. Hepatic lipid droplet biology: Getting to the root of fatty liver. Hepatology 2015;62(3):964-967.

Mashek DG, Wu C.  MUFAs. Advances in Nutrition 2015;6(3):276-277.

Mashek DG. Hepatic fatty acid trafficking: multiple forks in the road. Advances in Nutrition 2013;4(6):697-710.

Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MI, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. Journal of Clinical Investigation 2011;121(6):2102-2110.

Coleman RA, Mashek DG. Mammalian triacylglycerol metabolism: synthesis, lipolysis and signaling. Chemical Reviews 2011;111(10):6359-6386.

A complete list of publications is available via PubMed